Administration of C1-INH in a rat model of MI [111] improved cardiac function and reduced myocardial infarct size due to the inhibition of complement activation and leukocyte recruitment (due to lower expression of the endothelial adhesion molecules, P-selectin, and intercellular adhesion molecule 1 (ICAM-1). The gene discussed is ICAM1; the disease is myocardial infarction.