While some researchers have found that FTO expression was not modulated during differentiation of preadipocytes into mature adipocytes, some have even demonstrated that FTO expression is decreased during differentiation of primary preadipocytes isolated from human subcutaneous adipose tissue or preadipocytes derived from Simpson-Golabi-Behmel syndrome (SGBS) [17, 18]. Here, FTO is linked to Simpson-Golabi-Behmel syndrome.