Recent data suggest that FOXP3 expression in tumor cells could be an independent strong prognostic factor for distant metastases in breast cancer [28], but in contrast with these data, FOXP3 was also recently demonstrated to be a tumor suppressor gene, acting as a transcriptional repressor of SKP2 and HER2, two breast cancer important oncogenes [15, 29]. The gene discussed is SKP2; the disease is breast carcinoma.