VEGFA and preeclampsia: Thus, whereas late-onset preeclampsia was associated with a “basal” activation of the adenosine/NO/VEGF pathway, early onset preeclampsia exhibited a downregulation of this particularly via [29], suggesting that changes in cell proliferation/migration observed between late-onset preeclampsia and early onset preeclampsia may be explained by changes in the A2AAR/NO/VEGF signaling pathway activation.