On a final note, it should be mentioned that the value of biochemical dysfunctions in PBMCs as mirrors of CNS defects appears to extend well beyond dementia.For instance, FAAH and other elements of the endocannabinoid system show alterations in the blood that resemble those within the CNS in a broad spectrum of clinical conditions including Parkinson's and Huntington's disease, multiple sclerosis, schizophrenia, minor depression, and headache [163]. The gene discussed is FAAH; the disease is multiple sclerosis.