The deregulation of signaling pathways including MAPKs, TP53, sex steroid, Wnt/β-catenin, transforming growth factor β (TGFβ), PI3 K/AKT, cytokines, NF-κB, and Hedgehog (Hh) were found to be closely related with HCC development [191]. The gene discussed is TP53; the disease is hepatocellular carcinoma.