IL6 and Hypoalbuminemia: In fact, IL-6 promotes not only CRP upregulation, but also albumin downregulation in the liver, as well as protein synthesis [60] and thrombocytosis [61]; it is also important to underline that some of these characteristics are related to nutritional status, because an elevated CRP level, hypoalbuminemia, and low BMI reflect cachexia due to hypercytokinemia resulting from tumour progression.