Some are diagnostic and specific, such as anti-nuclear antibody (ANA) and anti-double stranded deoxyribonucleic acid antibody (a-ds DNA) for systemic lupus erythematosus (SLE) and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) for vasculitis. This evidence concerns the gene PRTN3 and systemic lupus erythematosus.