Genetically, TFEB RCC has been characterized by the fusion of the 5’ portion of Alpha, also known as MALATI (Genbank accession number AF203815), an intronless gene mapped at 11q12, with TFEB at 6p21 Inamura et al. 2012; Rao et al. 2012 with fewer than 30 cases reported to date Hora et al. 2009; Inamura et al. 2012; Rao et al. 2012; Camparo et al. 2008; Suarez-Vilela et al. 2011. The gene discussed is TFEB; the disease is renal cell carcinoma.