In patients with renal cell carcinoma (RCC), serum C-reactive protein (CRP) level (Steffens et al. 2012; Yasuda et al. 2012; Saito and Kihara 2010) and the Glasgow Prognostic Score (Ramsey et al. 2007; Lamb et al. 2012) have prognostic significance. This evidence concerns the gene CRP and hereditary clear cell renal cell carcinoma.