We also successfully detected PLK-cleaved R58 LAP-DP using the R58 antibody in fibrotic mice, suggesting that PLK dependent TGF-β1/3 activation was at least involved in murine hepatic fibrosis and that PLK-cleaved LAP-DP might be a marker for liver fibrosis. This evidence concerns the gene TGFB3 and Hepatic fibrosis.