Autoantibodies present in the sera of AMD patients, specifically those against PS and CEP adducts, and T cells (either producing IL-17 or not) could play a role in the pathogenesis of AMD and retinal aging by modifying the metabolic equilibrium of the retina and RPE or directly destroying retinal and RPE cells expressing autoantigens. This evidence concerns the gene IL17A and age-related macular degeneration.