The mitochondrial peroxidases, Prdx3 and Prdx4, were found to display expression changes in bladder cancer that related to disease prognosis [191], and Prdx3 upregulation was associated with increased cervical cancer risk [208]; H2O2-induced Prdx3 overexpression was observed in the eye lens in cataractogenesis [288]. The gene discussed is PRDX4; the disease is urinary bladder cancer.