The exact mechanism [15] has been further demonstrated, suggesting that VEGF and bFGF secretion were downregulated by taspine in human non-small cell lung cancer cell (A549 cell) and human umbilical vein endothelial cells (HUVECs), confirmed by the decreased mRNA level of VEGF and Flk-1/KDR after taspine treatment in HUVECs. Here, KDR is linked to small cell lung carcinoma.