ICAM1 and acute respiratory distress syndrome: To address the question whether RAGE and ICAM-1, which are known to be involved during lung inflammation [30, 31], mediate PC-induced inhibition of leukocyte recruitment in a disease relevant model of acute lung inflammation, we investigated neutrophil emigration during LPS-induced acute lung injury (ALI) in WT, Icam-1−/−, and RAGE−/− mice in response to PC.