For instance, ADAMTS-7 mRNA is found to be significantly increased in the cartilage of patients with rheumatoid arthritis (RA) and only slightly increased in the cartilage of patients with osteoarthritis (OA), whereas ADAMTS-12 mRNA is significantly increased in both OA and RA cartilage [10, 32]. This evidence concerns the gene ADAMTS7 and osteoarthritis.