Criteria were set as a 1.5-fold change threshold in the CAIA severity change and three genes were found including collagen triple-helix repeat-containing 1 (Cthrc1), C1q and TNF-related protein 3 (C1qtnf3), and ADAMTS-12, which were all associated with both gender and arthritis [105]. The gene discussed is ADAMTS12; the disease is Arthritis.