Interestingly, ADAMTS-12 was found to function as the downstream target of parathyroid hormone-like hormone/parathyroid hormone related peptide (PTHLH/PTHrP) in chondrocytes, and both PTHLH and ADAMTS-12 were all downregulated along with impaired chondrogenic differentiation within brachydactyly type E (BDE) [77]. This evidence concerns the gene ADAMTS12 and brachydactyly type E.