APOB and atherosclerosis: Using a slightly different model with ApoB and miR-33 double knockout (ApoB−/− miR-33−/−) mice, Horie et al. reported that miR-33 deficiency caused the upregulation of HDL and slowed the progression of atherosclerosis, that is, results similar to the application of anti-miR-33 by Horie et al. [106].