Following an examination of four possible miRNA transport modalities (microparticles, exosomes, Ago, and HDL transported miRNAs), Finn et al. [88] further noted that especially microparticles of CAD patients generally present lower levels of miRNAs as a result of decreased miRNA loading into microparticles; microparticles from CAD patients were also shown to be less sufficient with respect to miRNA delivery to cultivated cells (probably due to the lowered expression of developmental endothelial locus 1 (Del-1), a known mediator of endothelial microparticle uptake [86]). Here, FBXW7 is linked to coronary artery disorder.