We discovered co-regulated targets of this complex in vivo and during oncogene-induced senescence (OIS), including a novel tumor suppressor, the lncRNA UCA1. UCA1 is sufficient to induce senescence and does so in part by sequestering hnRNP A1 to specifically stabilize CDKN2A-p16INK mRNA. This evidence concerns the gene CDKN2A and neoplasm.