It will be informative to determine which Jak-STAT, TLR, and TGFβ pathway members (Figure 7N) are direct CAPERα/TBX3 targets, as the complex roles of these pathways in the senescence associated secretory phenotype, inducing or enforcing autocrine and paracrine senescence, and tumor progression are emerging (Hubackova et al., 2010; Senturk et al., 2010; Hubackova et al., 2012; Davalos et al., 2013). The gene discussed is TBX3; the disease is neoplasm.