RPS17 and Diamond-Blackfan anemia: Figure 2D shows a decrease in p62 protein levels by western blot analysis in DBA-derived LCLs compared to normal control cells, 3 independent experiments of which are quantified in Figure 2E. A significant decrease of p62 is also detected by IF in cells derived from DBA patients, which is highly significant when the total amount of p62 expression per cell area is measured (N>100, p<0.01) (Figures 2F-G). Lastly, electron micrographs in Figure 2H reveal the presence of many autolysosomes in the RPS17+/- mutant cells compared to only small lysosomes in the normal control cells.