Analogous to the miR-143/145 story, the investigators found that upregulated expression of miR-451a induced apoptosis and suppressed cell proliferation, invasion and metastasis in the esophageal carcinoma cell line EC9706 and modulated miR-451a targets Bcl-2, AKT and p-AKT (54). Here, AKT1 is linked to carcinoma of esophagus.