That SPIBlow/BATFhigh-ABC-DLBCL is significantly associated with mutation of MYD88 is consistent with the model recently proposed by Yang et al. of a role for SPIB/IRF4 heterodimers in repressing autocrine IFN secretion that limits ABC-DLBCL survival (16). The gene discussed is IFNA1; the disease is diffuse large B-cell lymphoma.