That SPIBlow/BATFhigh-ABC-DLBCL is significantly associated with mutation of MYD88 is consistent with the model recently proposed by Yang et al. of a role for SPIB/IRF4 heterodimers in repressing autocrine IFN secretion that limits ABC-DLBCL survival (16). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.