In contrast, the SPIBlow/BATFhigh meta-profile was most significantly enriched for genes associated with STAT3 activation in ABC-DLBCL (STAT3high_ABC_DLBCL_subgroup, FDR p-value = 2.85E-17), while among other signaling pathway signatures those linked to nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) in ABC-DLBCL were also significantly enriched (e.g. NFKB_UP_BCR_paper, FDR p-value = 2.22E-08; BASSO_CD40_SIGNALING_UP, FDR p-value = 6E-05) (Supplementary Table S7). The gene discussed is STAT3; the disease is diffuse large B-cell lymphoma.