That SPIBhigh/BATFlow-ABC-DLBCL is more significantly associated with genes expressed in resting B-cells is generally consistent with what is known of the normal function and expression pattern of SPIB which has previously been identified as a regulator of B-cell signaling pathways and a repressor of plasma cell differentiation (10–13). The gene discussed is SPIB; the disease is aneurysmal bone cyst.