Furthermore, the significant enrichment of genes on chr19 in the vicinity of SPIB, including genes previously identified as coordinately overexpressed in ABC-DLBCLs with amplification of chr19 by Lenz et al. (14), is consistent with chr19 amplification providing a pathogenetic mechanism in the SPIBhigh/BATFlow-ABC-DLBCL subgroup. The gene discussed is SPIB; the disease is diffuse large B-cell lymphoma.