In contrast, the enrichment in the SPIBlow/BATFhigh-ABC-DLBCL meta-profile of genes expressed in B-cells following IL21 and CD40L activation, STAT3-high ABC-DLBCL and NFκB and CD40 activation, points to combined activation of the STAT3 and CD40/NFκB pathways as likely mechanisms driving this subgroup. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.