IRF4 and diffuse large B-cell lymphoma: A recent study reported on the role of SPIB in ABC-DLBCL using biotin-tagged SPIB for ChIP-seq assays, and concluded that SPIB/IRF4 heterodimers were central to ABC-DLBCL pathogenesis potentially regulating B-cell receptor signalling pathways and interferon-α (IFNα) secretion downstream of MYD88 mutations (16).