We found that Atf6 causes upregulation of Srebp2 target genes, and while this modest increase in Srebp2 target genes in atf6 morphants did not appear to have a functional impact on cholesterol biogenesis, since atf6 morphants do not develop steatosis but are protected from it, it does suggest that Atf6 may suppress Srebp2 activity. The gene discussed is ATF6; the disease is steatosis.