As shown in Figure 3A, KLF2-transduced cultures showed a strongly reduced frequency of GFP+ cells and constant numbers of GFP+ cells (24 and 48 h after infection), whereas control-infected cells showed a constant frequency and an increase in the absolute cell numbers over time, indicating that KLF2-transduced, splenic B cells are impaired in proliferation or become apoptotic. The gene discussed is KLF2; the disease is infection.