A number of MAP kinase adaptor genes were also amplified in TCGA datasets, including the FGFR adaptor FRS2 and the EGFR family adaptor GRB7. GRB7 displayed an Achilles shRNA hairpin profile similar to KRAS (Fig. 6A), suggesting that GRB7 may be necessary for cancer cell survival/proliferation. The gene discussed is KRAS; the disease is cancer.