We identified cancer cell lines with NSD3 amplification for further experimental validation, including the non small-cell lung cancer (NSCLC) cell lines H1581 (7 copies Nsd3) and H-1703 (6 copies Nsd3), as well as the colorectal cancer cell line SW837 (5 copies Nsd3). Here, NSD3 is linked to non-small cell lung carcinoma.