APH1A and lung carcinoma: A chromosome 1q cluster with 12 amplified genes contained 4 genes with overall copy number versus mRNA expression correlation greater than 0.5, and the two most highly ranked genes in the amplicon were SETDB1 and APH1A. Interestingly, SETDB1 was recently identified as an important amplified cancer driver gene in lung cancer and melanoma [19], [20].