These gene included KRAS, PRKAB2, GRB7, BRD4, PRPF6, BCL9, PPFIA1 and NOTCH2. Other genes showed negative shRNA scores in a subset of the cancer cell lines, such as CCND1, NDUFC2, YEATS4, GTPBP4, and CHD1L (Fig. S3). Here, GRB7 is linked to cancer.