NOTCH2 and cancer: The list also included a number of targets currently in clinical development across the industry, such as CDK6, PIK3CA, PIK3C2B and NOTCH2. CDK6 on chromosome 7q was amplified as a single gene in lung squamous cancer and glioblastoma, while PIK3CA resided on a chromosome 3q cluster with 6 other genes and was amplified in multiple cancer types (Figure 2) [17].