Effect of daily oral administration of pentoxifylline (PTX, 30 mg⋅kg−1, last 4 weeks) on high fructose high fat diet- induced insulin resistance (IR, 10% fructose in drinking water plus 25% unsaturated fat in diet, for 12 weeks) associated changes in serum levels of fasting glucose, fructosamine and insulin. This evidence concerns the gene INS and Insulin resistance.