CYBB and chronic granulomatous disease: However, the results in Ncf1−/− and gp91phox−/− mice were not consistent with those observed in CGD patients, since dextran sulfate sodium (DSS)-induced colitis was indistinguishable between Ncf1−/− mice and their wild type (WT) counterparts, whereas in gp91phox−/− mice DSS-induced colitis was milder than in the WT groups [16].