In particular, a point mutation in the Ncf1 gene of B10.Q mice impairs the production of reactive oxygen species (ROS) leading to increased susceptibility to infections with Staphylococcus xylosus, Staphylococcus aureus and Burkholderia cepacia[10], and to the development of severe chronic autoimmune disorders such as collagen-induced arthritis and experimental autoimmune encephalopathy [11]–[13]. This evidence concerns the gene NCF1 and infection.