Since bowel inflammation, resembling Crohn's disease (CD), is a common complication of CGD, with patients presenting elevated titers of Crohn's associated antibodies even in the absence of active colitis [15], gp91phox−/−, Ncf1−/− and –more recently- p40phox−/− mice have been used to understand how the lack of ROS-production associates with colitis [19]–[21]. Here, CYBB is linked to chronic granulomatous disease.