After the second cycle of colitis induction, D21, the colon of WT mice had ulcers, and epithelial regeneration with glandular hyperplasia without nuclear atypia (Fig. 3), and the inflammatory infiltrate was mostly comprised of CD3+ lymphocytes (score: +++), a few CD11b+ macrophages (score: +), and less than 10% granulocytes and plasmocytes (score: 0 to +) (Figs. 2C, 3B, C & D). Here, ITGAM is linked to colitis.