The Ncf1* mice presented a more severe injury of the colonic tissue, with ulcers reaching the muscularis propria (Fig. 4A), severe dysplasia with small back to back glandules with atypical mitoses and anisocarioses (Figs. 2B, 4A), and the composition of the inflammatory infiltrate was mainly CD3+ (score: +++) and B220+ lymphocytes (score: ++), CD11b+ macrophages (score: ++), plasmocytes (score: +), and a reduced amount of granulocytes (less than 5%) (Figs. 2C, 4B–E). Here, ITGAM is linked to ulcer disease.