NCF1 and chronic granulomatous disease: Moreover, since DSS is a chemically induced inflammation of the large bowel, which damages the mucosa and allows the fecal matter and therefore enteric bacteria across the mucosal barrier, it is possible that, similarly to CD and CGD, the Ncf1* mice have a failure in bacterial clearance leading to persistent bacterial/luminal contents in the bowel wall which may drive the chronic bowel inflammation.