CYBB and chronic granulomatous disease: Since CGD is caused by point mutations in the NOX2 genes and the disease-associated colitis has a chronic profile, inducing two cycles of colitis with DSS intercalated by a resting period in mice with a point mutation in the Ncf1 gene, the proposed colitis model presents an excellent model to study how the lack of oxidative burst can lead to the development of IBD with features reminiscent of CGD colitis.