In a study, Jhao et al. reported the stimulation of Toll-like receptor-9 (TLR9) presented on the intracranial GL261 gliomas bearing mice by CpG oligodeoxynucleotide (CpG) conjugated SWCNTs and concluded that functionalized CNTs were responsible for augmenting CpG prostimulator function by facilitating its uptake through the TLR9 receptor mediated endocyte localization into the glioma cells [104]. Here, TLR9 is linked to central nervous system cancer.