In a complementary study by Brookes et al., increases in iron acquisition proteins (Divalent metal transporter-1, DMT-1; Transferrin receptor-1, TfR1) and decreases in proteins related to cellular iron efflux (FPN; Hephaestin, Heph) were noted in colonic tumors when compared to non-involved mucosa[1]. The gene discussed is TFRC; the disease is colonic neoplasm.