In 1994 the International Lymphoma study group [10] unified within a single “diffuse large B cell lymphoma” category, three high-grade lymphomas originally defined as “histiocytic” [11] and then, with updated terminology, named centroblastic lymphoma and its variants [12], immunoblastic B cell lymphoma [12, 13], and large B cell anaplastic Ki1+ lymphoma [14]. The gene discussed is TNFRSF8; the disease is lymphoma.