In earlier studies, where FISH was used to analyze MYC and BCL2 rearrangements, DLBCL with concomitant MYC/BCL2 rearrangements had dismal survivals, with about 60 % of patients dying within 6 months, and a 5-year survival of less than 10 % [54]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.