PKA (protein kinase A) mediated phosphorylation of HDAC8 (histone deacetylase 8), under normal and tumor conditions, recruits EST1B (ever shorter telomeres 1B) and Hsp70/Hsp90 in a complex in a manner which precludes CHIP from ubiquitinating EST1B, which is otherwise a substrate of CHIP [111]. Here, HDAC8 is linked to neoplasm.