The tumour-suppressor gene TP53 encodes a protein p53 implicated in the pathogenesis of many cancers. TP53 mutations have been reported not only in about 30% of gliomas [21, 22], mainly low-grade ones, but also in secondary glioblastomas (65% versus 28% in primary GBM) [23]. The gene discussed is TP53; the disease is glioma.