A family member's serious or chronic illness, long-lasting financial difficulties, and having been afraid of a family member statistically significantly increased the risk of having combination therapy, that is, a tablet- and insulin-treated form of diabetes later in life without controlling the confounding factors (OR 2.18, 95% CI 1.39–3.43, OR 2.29, 95% CI 1.45–3.62, and OR 1.92, 95% CI 1.08–3.40), respectively. This evidence concerns the gene INS and diabetes mellitus.