THPO and hypersplenism: As we already know, patients with hepatitis virus infections may have neutropenia and thrombocytopenia; the cause of thrombocytopenia is multifactorial in many patients: hypersplenism, reduced thrombopoiesis as a result of decreased production of endogenous thrombopoietin by the liver, marrow suppression by hepatitis viruses, dysregulation of immunity [21].