TSHR and undifferentiated carcinoma: Methylated thyroid specific genes are the following: Na/I symport, (Sodium iodide symporter (NIS)) in 22% PTC [44,45]; TSH receptor (Thyroid-stimulating hormone receptor) in 34–59% of thyroid cancer [46,47]; Pendrin (SLC5A8/ Apical Iodide Transporter (AIT)) in 33% PTC (associated with BRAF mutation) [39]; TTF-1 (Thyroid transcription factor-1) in 60% of the undifferentiated carcinomas [48].