HP and obesity due to melanocortin 4 receptor deficiency: The adipokine haptoglobin (HP), a plasmatic glycoprotein with tetrameric structure of 2 alpha and 2 beta polypeptides that are covalently binding by disulfide bonds [6], is a positive acute phase protein synthesized in the liver and expressed by WAT, exhibiting capacity to recruit monocytes and macrophages and thus playing an important role in the link between obesity and chronic systemic inflammation [7, 8].