NLRX1 and bacterial infectious disease: Although NLRX1 expression was unaffected by viral and bacterial infection, lipopolysaccharide treatment, or hypoxia (Fig. 1A and data not shown), removal of extracellular glucose or addition of the glycolysis inhibitor 2-deoxyglucose (2-DG) significantly blunted NLRX1 expression (Fig. 1B).