To further evaluate the clinical relevance of the catalytic activity of RARRES3 and its association with differentiation markers in BC, we initially focused on 13 well-known PPAR target genes associated with differentiation processes (Sertznig et al, 2007), including lipid metabolism enzymes, fatty acid transport and uptake genes, the peroxisome maintenance gene, and gene transcription. This evidence concerns the gene PLAAT4 and breast cancer.