PPARD and metastatic neoplasm: Similarly, lung metastatic tumors in mice originated from RARRES3-expressing LM2 cells also showed increased expression of some differentiation attributes, including the differentiation transcription factor GATA3, as well as some PPAR targets (PPARD, PPARG, and ACSL5) significantly correlated with RARRES3 expression in primary tumors (Fig 6F).