The acquisition of low expression levels of RARRES3 in ER− BC primary tumors that metastasize to the lung is directly associated with a reduction in GATA differentiation genes (Chou et al, 2010) and inversely correlated with expression of the EZH2 pluripotency gene marker (Sparmann & van Lohuizen, 2006). The gene discussed is QRSL1; the disease is breast cancer.