PLAAT4 and breast cancer: In contrast, the maintenance of a stem phenotype, associated with self-renewal properties, is critical for cells to establish new lesions (Al-Hajj et al, 2003; Dontu et al, 2003; Li et al, 2007; Liao et al, 2007), which in ER− BC would be favored by the loss of expression or catalytic activity of RARRES3.