Mutations in these genes appear to be either specific to ICC, as is the case of IDH1 and IDH2 (p=0.0005), or cluster within this cancer type as is the case for ARID1A, BAP1, and PBRM1 that were found in 34.3% (24/70) of ICC. This evidence concerns the gene BAP1 and intrahepatic cholangiocarcinoma.