ICC were characterized by a high prevalence of IDH1/IDH2 mutations (20.0%) and the significant involvement of chromatin remodeling genes PBRM1 (14.3%), BAP1 (14.3%) and ARID1A (11.4%) (Figure 3), as described[32, 33]. This evidence concerns the gene IDH1 and intrahepatic cholangiocarcinoma.