Mutations were differently distributed across the different tumour subtypes: IDH1/IDH2 (p=0.0005) were restricted to ICC and BAP1 mutations were all found in ICC (p=0.0097) with the exception of one GBC, while KRAS (p=0.0019) and TP53 (p=0.0019) were more represented in ECC and GBC, respectively (Table 2). This evidence concerns the gene KRAS and intrahepatic cholangiocarcinoma.