Alterations in chromatin remodeling genes (ARID1A, BAP1, IDH1, IDH2, PBRM1, SMARCB1) were found in 30.7% (47/153) of cancers in our series, confirming recent reports on the significant involvement of these genes in cholangiocarcinoma [9, 13]. This evidence concerns the gene PBRM1 and cholangiocarcinoma.