The activated Phosphoinositide 3-kinase (PI3K)/AKT pathway stimulates mTOR to phosphorylate its downstream effectors p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1), mediating the expression of genes associated with tumor malignancy[25], [26]. This evidence concerns the gene MTOR and neoplasm.