Some miRNAs regulate cell cycle and proliferation (Hsa-miR-139-5p, and Hsa-miR-320d) by repressing G protein-coupled receptor 56 (GPR56), whose over-expression plays an inhibitory role in melanoma progression [179], by controlling ribosome assembly (Nuclear Import 7 Homolog, NIP7) [180], and by regulating proliferation, repressing SHC SH2-domain binding protein 1 (SHCBP1), that is a proliferation controller downstream of Shc [181]. This evidence concerns the gene ADGRG1 and melanoma.