A recent publication [193] suggests that FOXM1 promotes cancer invasion and metastasis via TGF-beta/SMAD3 pathway activation, but it is also able to induce EMT-like changes in hepatocellular carcinoma for a review see [194], demonstrating a clear role of this gene in G3 hystologic phenotype. The gene discussed is SMAD3; the disease is hepatocellular carcinoma.