SMARCAL1 and Schimke immuno-osseous dysplasia: Despite the clear role of HARP in DNA repair, replication fork restart and the presence of the SIOD disease phenotype of biallelic hsHARP mutations, a biallelic deletion in mouse HARP, that removes both the RPA binding motif and the first HARP domain repeat and a biallelic deletion in dmHARP that results in non-expression, did not display significant growth defects in mice and flies under non-stressful environmental conditions [12].