IFNA1 and viral infectious disease: In particular, following the initial observation that virus infection enables mouse splenic DCs for CD8+ T cell cross-priming through IFN-α/β production [68], type I IFNs were subsequently shown to mediate CpG DNA-, dsRNA- and LPS-induced enhancement of antigen cross-presentation by increasing MHC I mRNA transcription and stability [70,71,72].