Initial preclinical studies testing HDAC inhibitors in mouse models of polyglutamine disorders were carried out using broad-spectrum HDAC inhibitors; however, the clinical use of these broadly-acting compounds for neurodegenerative disorders is limited by their known toxicity, hence, it is becoming clear that inhibitors with subtype-selectivity may prove to be more beneficial for targeting neurological disease symptoms and minimizing harmful side effects [4]. Here, HDAC9 is linked to nervous system disorder.