Genetic reduction of HDAC3 using Hdac3 (+/−) heterozygous mice has been reported, and was not found to ameliorate disease phenotypes when crossed with R6/2 transgenic mice; however the overall protein levels of HDAC3 were only reduced 20%, hence it is likely that the these reductions were not sufficient to observe significant changes in HD phenotypes [70]. Here, HDAC3 is linked to Huntington disease.