MAPK8 and diabetic cardiomyopathy: MAPK signaling pathway, which includes three major subfamilies known as c-Jun N-terminal kinases (JNK), P38, and extracellular signal regulated protein kinases (ERK), have been reported to be important mediators for the cardiac remodeling process in diabetic cardiomyopathy and participate in the development of myocardial damage [32], [33].