In colon cancer cells, curcumin reduced miR-21 via AP-1 (transcription factor complex composed of c-Jun and c-Fos, mainly) regulation, and in the human promyelocytic cell line, HL-60, phorbol 12-myristate 13-acetate (PMA) induced miR-21 expression by AP-1 activation [17],[20]. Here, JUN is linked to malignant colon neoplasm.