Among the genes regulated by CBX7 in human thyroid carcinoma cells we concentrated our attention on FOS, FOSB and EGR1 (Table 1) that were positively regulated, and SPP1, SPINK1 and STEAP1 (Table 2) that were, conversely, negatively regulated by CBX7, since these genes are known to play a relevant role in the acquisition of a fully malignant phenotype. Here, SPINK1 is linked to thyroid gland carcinoma.