The association analysis between clinical manifestations and autoantibodies revealed that there were associations between anti-Sm antibody (P < 0.001), anti-rRNP antibody (P < 0.05), and malar rash; between anti-dsDNA antibody and nephropathy; between anti-RNP antibody, anti-SSA antibody and pulmonary arterial hypertension (PAH); and between anti-SSB antibody and hematological involvement (P < 0.05). The gene discussed is RNPC3; the disease is pulmonary arterial hypertension.