Instead of coupling with ZAP-70 for signalling by the CD3ζ subunits, FcRγ associates with the Syk pathway and such “rewired” downstream signalling confers stronger phosphorylation of signalling molecules and higher calcium influx which intensifies the TCR-derived signals in lupus T cells [17]. The gene discussed is FCER1G; the disease is systemic lupus erythematosus.