In a double-blind, placebo-controlled trial, 85 patients with mild to moderately active SLE were randomized to receive 6 infusions of anti-CD40L at doses of 2.5, 5, and 10 mg/kg and placebo at 0, 2, 4, 8, 12, and 16 weeks [71]. Here, CD40LG is linked to systemic lupus erythematosus.