However, a replication study, which genotyped SNPs mapped in CDKAL, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and FTO previously associated with T2D in Caucasians, did not provide any evidence for association with T2D or obesity among full-heritage Pima Indians. The gene discussed is EXT2; the disease is type 2 diabetes mellitus.