Antioxidant status in Nigerian men with prostate disorders has not been fully investigated; therefore, the aim of this study is to determine the antioxidant status as indicators of oxidative stress in patients with benign prostate hyperplasia (BPH) and prostate cancer in Enugu, South-East Nigeria, and see if the value can serve as adjunct to PSA levels in diagnosis and management of patients with these prostate disorders. This evidence concerns the gene KLK3 and prostate cancer.